A little late to the game on this thread, but I have had great luck setting up Wink as a primary controller to ISY, and for 40 bucks you can get all the advantages (free phone app, Relay controllers, great Echo compatibility without Hue Emulator hacks, better IFTTT integration, etc.) with no real downside. And by making Wink the primary controller, it is much easier to add zwave devices to the network - since it doesn't need an ethernet cable, simply plug it in near your new device and include the new device... Plus the problems with Wink are slowly disappearing, and there is a promise of local control "this summer"...
On the ISY side, the programmability and instant response is there, something that Wink still doesn't really have. So you get the best of both worlds...
