The load is a mixture of incandescent and LED lighting controlled mostly by 2477D's with a few LampLincs thrown in. All the components are purchased in the last 3 months. Over the last 2 days I ran and re-ran both scenes and programs of various combinations of devices trying to identify interference probably 50 times. Invariably, one or two of the devices would not respond correctly. For example, I would have a scene to turn off a group of lights, and when I ran the scene either manually or with a program, one or two devices failed to turn off even though ISY reported the device was off. When I queried the offending device, it updated its state correctly, showing it was in fact still ON. Both the device and location of the offending device was random, no pattern.
On advice from Insteon tech support, I tried running a program with a time delay between each command, and it worked flawlessly. I then deleted the 2 second ramp rate delay, and deleted the time delays, and suddenly everything started to work with 100% reliability.