You likely could switch most of the switch out with a standard switch. If your load is wired directly to the 2476D you will have little issue switching. If the load is wired separately to control a remote responder, you will have trouble. The Instean system allows the linking of devices without a home controller. But few people operate like this. The ISY is a great controller and worth buying if you keep the switches. Start with the below-linked manual. After that, check out the UD Wiki.
SwitchLinc Dimmer 2476D (insteon.com)
Universal Devices, Inc. Wiki (universal-devices.com)