I also just got a 2411R to use with my Harmony Remote and ISY-99.
Using the suggestions on how to link buttons I created them all with A-H on and off, then I-L seem to do ON only. I was not successful in getting I-L to be toggles.
The grouping of the devices is also a little strange with "A" as the root device, and the other devices all fall under it.
That said I used the "+" button on the remote to turn on a scene in my Family Room which has light I would like on sometimes, and the "E" button to turn off all the lights in the family room and kitchen. Fairly simple and does what I need for now. My original idea was to be able to toggle with key presses which would allow more functionality without dedicating more buttons.
Any suggestions on other ways to do it would be appreciated.