Posting this for others that may run into this issue. I could not find this solution in the Forum...
Upgraded from 4.9.x to 5.3.4 on 7/27/22
Programs stopped working
Everything else except Programs seem to work fine (ie: scenes, Alexa, etc)
Note: there were green arrows on each of my Programs (it didn’t dawn on me what that meant!)
Rebooted ISY
Programs still not working
When I run a Program directly (ie: Run “If”, etc) it does not work
No conditions present at Top Level “My Programs” folder
Nothing is getting reported in the Summary section (ie: Last Run Time, etc)
All Programs show as Enabled
Solution
From Details I selected a Program and then clicked on Save Changes
The system went through and saved changes for all of my Programs
Tested multiple Programs and they all worked!