Breezyken

Can I use both my ISY994i and a Smarthome Insteon Hub (2245-222) in the same installation? WHY?? I have an Amazon Echo which I can use for Insteon voice control, but it requires the smarthome hub as an interface. I understand that the smarthome hub is not very user friendly or as flexible as ISY, but I would like to be able to control several insteon devices by voice. Do you think they will play nice together?