ditto. I used to have tons of IR, IP and serial control in my network resources but it was a mess. I switched to using Simple control Hub, sending REST from ISY to start activities. It works great. Simple Control does not have yet direct Smart Home commands in Alexa but through ISY programs I can control all AV activities using Alexa. It is great to have one, central repository of all AV control commands in the Simple Control Hub that shared by all iOS devices remote controls and ISY.
I finally cleaned tons of low level staff from Network resources. Not having sub second delays, feedback, ISY just not well suited for AV control.